SCHEMBL27499136

SCHEMBL27499136

O=S(=O)(O)C1=Cc2ccccc2SN=C1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27528699 0.73 TRPA1 (0.33)
SCHEMBL7849227 0.69 TRPA1 (0.33)
SCHEMBL27366019 0.69 TRPA1 (0.31)
SCHEMBL3688542 0.67 TSHR (0.31) TSHRSMN1; SMN2
SCHEMBL27432698 0.66 ALOX12 (0.31)
SCHEMBL7847311 0.66 GPR84 (0.41)
SCHEMBL8555 0.65 TRPA1 (0.35)
Urea SCHEMBL9162913 0.62 BCHE (0.37) TSHR
SCHEMBL27470518 0.62 TSHR (0.33) TSHRSMN1; SMN2
SCHEMBL20145049 0.61 TRPA1 (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1195748-C 1,2-benzothiazepines for the treatment of hyperlipidemic diseases SEARLE & CO (US) 2005-04-06 CN disclosed
CN-1346351-A 1,2-benzothiazepines for the treatment of hyperlipidemic diseases SEARLE & CO (US) 2002-04-24 CN disclosed