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Tryptophan

Tryptophan

SCHEMBL27432308

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.N=C(N)NCCC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACE

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 2/20 0.43
▸ PTH1R Q03431 4/20 0.42
▸ GLP1R P43220 11/20 0.41
▸ IL23R Q5VWK5 2/20 0.40
▸ RXFP1 Q9HBX9 1/20 0.40
▸ CCKBR P32239 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL27493966 0.98 KEAP1 (0.42) KEAP1PTH1RGLP1RIL23RRXFP1
Tryptophan SCHEMBL27546659 0.97 KEAP1 (0.41) KEAP1PTH1RGLP1RIL23R
Tryptophan SCHEMBL27501630 0.95 IL23R (0.45) GLP1RIL23RCCKBR
Tryptophan SCHEMBL27389650 0.94 TUBB4A (0.44) PTH1RGLP1RIL23R
Tryptophan SCHEMBL27459392 0.91 KEAP1 (0.43) KEAP1GLP1R
Tryptophan SCHEMBL27677376 0.91 TLR2 (0.37) KEAP1PTH1RGLP1R
Tryptophan SCHEMBL27503845 0.91 GHSR (0.39) GLP1R
Tryptophan SCHEMBL27376884 0.90 PTH1R (0.42) KEAP1PTH1RGLP1RIL23RRXFP1
Tryptophan SCHEMBL27342636 0.89 CTSC (0.38) KEAP1GLP1R
Dl-Tryptophan SCHEMBL27789301 0.89 CTSC (0.41) KEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1137736-A Method for breeding cows by feeding highly condensed nutritious feed AJINOMOTO KK (JP) 1996-12-11 — — CN disclosed
CN-1108502-A Raw syrup of composite orchid nutrient food and making technology thereof ZHOU FENGJUN (CN) 1995-09-20 — — CN disclosed
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