Chlorpyrifos-Methyl

Chlorpyrifos-Methyl

SCHEMBL27546

COP(=S)(OC)Oc1nc(Cl)c(Cl)cc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 1.00
MEN1 O00255 1/20 1.00
KMT2A Q03164 1/20 1.00
ALDH1A1 P00352 3/20 0.69
CYP3A4 P08684 3/20 0.69
HSD17B10 Q99714 3/20 0.69
TSHR P16473 2/20 0.69
MAPK1 P28482 2/20 0.69
MAPT P10636 1/20 0.69
ALOX15 P16050 1/20 0.69
ALOX12 P18054 1/20 0.69
ATM Q13315 1/20 0.69
L3MBTL1 Q9Y468 1/20 0.69
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
THRB P10828 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chlorpyrifos-Methyl SCHEMBL21647865 1.00 TDP1 (1.00) TDP1MEN1KMT2AALDH1A1CYP3A4
Chlorpyrifos-Methyl SCHEMBL17274494 0.89 TDP1 (0.80) TDP1MEN1KMT2AALDH1A1CYP3A4
Chlorpyrifos SCHEMBL1069405 0.89 ALDH1A1 (0.89) TDP1MEN1KMT2AALDH1A1CYP3A4
Chlorpyrifos-Methyl SCHEMBL1073936 0.88 TDP1 (0.78) TDP1MEN1KMT2AALDH1A1CYP3A4
SCHEMBL11431189 0.83 TDP1 (0.71) TDP1MEN1KMT2AALDH1A1CYP3A4
Chlorpyrifos-Methyl SCHEMBL23212099 0.82 TDP1 (0.67) TDP1MEN1KMT2AALDH1A1CYP3A4
Chlorpyrifos SCHEMBL21680 0.81 ALDH1A1 (1.00) TDP1MEN1KMT2AALDH1A1CYP3A4
Chlorpyrifos SCHEMBL7908295 0.81 ALDH1A1 (1.00) TDP1MEN1KMT2AALDH1A1CYP3A4
Chlorpyrifos SCHEMBL18228939 0.80 ALDH1A1 (0.97) TDP1MEN1KMT2AALDH1A1CYP3A4
Chlorpyrifos SCHEMBL28945660 0.80 ALDH1A1 (0.97) TDP1MEN1KMT2AALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 18519 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4734762-A1 BAIT COMPOSITIONS FMC Corporation (US) 2026-05-06 EP claimed
EP-4719059-A1 INCREASED PALATABILITY OF INSECTICIDAL INSECT BAITS Bio Logic Crop Science, S.L. (ES) 2026-04-08 EP claimed
US-20260083130-A1 NOVEL SULFONATE BENZAMIDE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS FMC CORP (US) 2026-03-26 US claimed
US-20260083129-A1 PYRAZOLE AMIDE INSECTICIDES FMC CORP (US) 2026-03-26 US claimed
EP-4710766-A1 MIXTURES OF AMBRUTICIN WITH AT LEAST ONE FURTHER PESTICIDE BASF SE (DE) 2026-03-18 EP claimed
US-12568969-B2 Pyridine compounds for controlling invertebrate pests FMC CORPORATION (US) 2026-03-10 US claimed
CN-121577800-A Non-targeted screening multi-pesticide residue detection method based on high-resolution mass spectrum 常州市食品药品纤维质量监督检验中心(常州市粮油质量监督检测站、常州纤维检验所) 2026-02-27 CN claimed
EP-4114183-B1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2026-02-25 EP claimed
EP-4697936-A1 METHOD FOR THE PRODUCTION OF DIETARY FIBERS INTENDED FOR THE FOOD INDUSTRY Industrie Rolli Alimentari S.p.A. (IT) 2026-02-25 EP claimed
WO-2025244856-A1 METHODS AND COMPOSITIONS RELATING TO ELQ COMPOUNDS OREGON HEALTH & SCIENCE UNIVERSITY (US) 2025-11-27 WO claimed
US-4489068-A Method and composition for enhancing the insecticidal activity of certain organophosphorus compounds THE DOW CHEMICAL COMPANY (US) 1984-12-18 US claimed
EP-0124253-A2 Agricultural compositions, methods of preparing agricultural compositions, and methods of using agricultural compositions THE DOW CHEMICAL COMPANY (US) 1984-11-07 EP claimed
EP-0017738-B1 AN INSECTICIDAL AND MITICIDAL COMPOSITION WHICH CONTAINS A CARBAMATE AND AN ORGANIC PHOSPHORUS COMPOUND, AND A METHOD OF CONTROLLING INSECTS AND MITES THEREWITH IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-08-08 EP claimed
EP-0113525-A1 Formulations of synthetic, organic, oil-soluble insecticides having increased effectiveness THE DOW CHEMICAL COMPANY (US) 1984-07-18 EP claimed
EP-0110157-A1 Granular pesticide composition PENNWALT CORPORATION (US) 1984-06-13 EP claimed
US-4440746-A POLYVINYL ALCOHOL AND BORATE PENNWALT CORPORATION (US) 1984-04-03 US claimed
EP-0099667-A1 Increasing the effectiveness of synthetic, organic, oil-soluble insecticides THE DOW CHEMICAL COMPANY (US) 1984-02-01 EP claimed
EP-0080516-A1 Stable insecticide containing latexes, method of making and method of distributing insecticide THE DOW CHEMICAL COMPANY (US) 1983-06-08 EP claimed
US-4380537-A ORGANO PHOSPHORUS COMPOUND AND A LACTONE THE DOW CHEMICAL COMPANY (US) 1983-04-19 US claimed
US-4303642-A Corn rootworm control THE DOW CHEMICAL COMPANY (US) 1981-12-01 US claimed