Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Phenanthrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 6/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.92 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.92 |
| ▸ | TSHR | P16473 | 3/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.92 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.71 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenanthrene SCHEMBL31256056 | 1.00 | CYP2A6 (0.92) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL28699478 | 1.00 | CYP2A6 (0.92) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL27458043 | 0.96 | CYP2A6 (1.00) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL8873977 | 0.96 | CYP2A6 (1.00) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL1330750 | 0.96 | CYP2A6 (1.00) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL30932938 | 0.96 | CYP2A6 (1.00) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL7643 | 0.96 | CYP2A6 (1.00) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL29477074 | 0.96 | CYP2A6 (1.00) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 | |
| Phenanthrene SCHEMBL29358486 | 0.96 | CYP2A6 (1.00) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 | |
| Chrysene SCHEMBL17075383 | 0.93 | HPRT1 (0.93) | CYP2A6ALDH1A1HSD17B10TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109824942-A | The preparation and its application of hybrid inorganic-organic materials composite flame-retardant agent | 西北师范大学 | 2019-05-31 | — | — | CN | claimed |
| WO-2024061002-A1 | N-HETEROCYCLIC BORYLOXY METAL COMPLEX AND PREPARATION METHOD THEREFOR AND USE THEREOF, AND COPOLYMERIZATION REACTION OF ETHYLENE AND NORBORNENE | 中国石油天然气股份有限公司 | 2024-03-28 | — | — | WO | disclosed |
| CN-108264631-B | Curing agent and resin composition using the same | 协立化学产业株式会社 | 2020-07-14 | — | — | CN | disclosed |
| CN-104428339-B | Curing agent and resin composition using the same | 协立化学产业株式会社 | 2020-01-07 | — | — | CN | disclosed |
| CN-109824942-A | The preparation and its application of hybrid inorganic-organic materials composite flame-retardant agent | 西北师范大学 | 2019-05-31 | — | — | CN | disclosed |
| CN-106433124-B | A kind of halogen-free resin composition of high frequency, High-Speed Printed Circuit Board curing agent containing esters | 无锡宏仁电子材料科技有限公司 | 2019-01-25 | — | — | CN | disclosed |
| CN-108785532-A | A kind of Chinese medicine preparation and preparation method thereof for treating burn and scald | 王�华 | 2018-11-13 | — | — | CN | disclosed |
| CN-105980441-B | Epoxy resin composition, curable resin composition, its solidfied material and semiconductor device | 日本化药株式会社 | 2018-05-08 | — | — | CN | disclosed |
| CN-106433124-A | Halogen-free resin composition containing ester curing agent for high-frequency and high-speed printed-circuit board | 无锡宏仁电子材料有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-103636286-B | Surface sealant for optical semiconductor, method for manufacturing organic EL device using same, organic EL device, and organic EL display panel | 三井化学株式会社 | 2017-02-15 | — | — | CN | disclosed |
| CN-104232016-B | The main binding agent being made up of polyorganosiloxane compounds | LINTEC CORP. (JP) | 2017-01-04 | — | — | CN | disclosed |
| CN-1214073-A | Ferroelectric liquid crystal mixture | HOECHST AG (DE) | 1999-04-14 | — | — | CN | disclosed |