Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 9/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 6/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | GCK | P35557 | 4/20 | 0.40 |
| ▸ | PDE2A | O00408 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27467646 | 0.84 | KCNH2 (0.46) | PTGDRTBXA2RKCNH2GCKPDE2A | |
| SCHEMBL27502236 | 0.84 | KCNH2 (0.46) | PTGDRTBXA2RKCNH2GCKPDE2A | |
| SCHEMBL27558086 | 0.83 | GCK (0.44) | PTGDRTBXA2RKCNH2GCKPDE2A | |
| SCHEMBL27558004 | 0.83 | ALDH1A1 (0.46) | ALDH1A1PTGDRTBXA2RKCNH2GCK | |
| SCHEMBL27558109 | 0.81 | GCK (0.47) | PTGDRTBXA2RKCNH2GCKPDE2A | |
| SCHEMBL27558059 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4ENPC1TP53HPGD | |
| SCHEMBL27578470 | 0.81 | GCK (0.47) | PTGDRTBXA2RKCNH2GCKPDE2A | |
| SCHEMBL27765336 | 0.81 | GCK (0.42) | ALDH1A1PTGDRTBXA2RKCNH2GCK | |
| SCHEMBL2641961 | 0.77 | KCNH2 (0.46) | PTGDRTBXA2RKCNH2GCKPDE2A | |
| SCHEMBL2642548 | 0.77 | KCNH2 (0.46) | PTGDRTBXA2RKCNH2GCKPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1329386-C | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-01 | — | — | CN | disclosed |
| CN-1649859-A | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-08-03 | — | — | CN | disclosed |