Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27561515 | 0.78 | EGFR (0.48) | MAPTGAAKDM4EALDH1A1MEN1 | |
| SCHEMBL27582035 | 0.77 | P2RY4 (0.40) | MAPTGAAKDM4EMAPK1L3MBTL1 | |
| SCHEMBL27561352 | 0.74 | KDR (0.47) | MAPTRAB9AGAANPC1ALDH1A1 | |
| SCHEMBL39057 | 0.73 | MAPT (1.00) | MAPTRAB9AGAAKDM4ETHRB | |
| SCHEMBL1459772 | 0.73 | MAPT (1.00) | MAPTRAB9AGAAKDM4ETHRB | |
| SCHEMBL27564358 | 0.73 | PTGS1 (0.43) | MAPTRAB9AGAAKDM4ENPC1 | |
| SCHEMBL1921461 | 0.72 | RAB9A (0.72) | MAPTRAB9AGAAKDM4ETHRB | |
| SCHEMBL857983 | 0.71 | TTBK1 (0.62) | MAPTRAB9AGAAKDM4ETHRB | |
| SCHEMBL10480098 | 0.70 | ALDH1A1 (0.65) | MAPTRAB9AGAAKDM4ETHRB | |
| SCHEMBL25634740 | 0.70 | GAA (0.80) | MAPTRAB9AGAAKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | disclosed |