Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27312907 | 0.99 | MTNR1A (0.41) | MTNR1ACHRM2CHRM4CHRM1DRD3 | |
| SCHEMBL27585383 | 0.83 | MTNR1A (0.44) | MTNR1ACHRM2CHRM4CHRM1DRD3 | |
| SCHEMBL27570842 | 0.80 | MTNR1A (0.40) | MTNR1ACHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL28229934 | 0.80 | MTNR1A (0.55) | MTNR1ACHRM2CHRM4CHRM1DRD3 | |
| SCHEMBL27807046 | 0.77 | CHRM2 (0.44) | MTNR1ACHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL27668336 | 0.75 | MTNR1A (0.39) | MTNR1ACHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL27844281 | 0.73 | MTNR1A (0.49) | MTNR1ACHRM2CHRM4CHRM1DRD3 | |
| SCHEMBL27528752 | 0.73 | ALDH1A1 (0.35) | MTNR1AMEN1ALDH1A1KMT2A | |
| SCHEMBL27478880 | 0.70 | SRD5A1 (0.39) | MTNR1ACHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL27929079 | 0.70 | SRD5A1 (0.39) | MTNR1ACHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100415737-C | Indole derivatives for the treatment of CNS disorders | LUNDBECK & CO AS H (DK) | 2008-09-03 | — | — | CN | disclosed |
| CN-1446211-A | Indole derivatives for the treatment of CNS disorders | LUNDBECK & CO AS H (DK) | 2003-10-01 | — | — | CN | disclosed |
| CN-1439004-A | Indole derivatives for the treatment of central nervous system disorders | LUNDBECK & CO AS H (DK) | 2003-08-27 | — | — | CN | disclosed |