Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27575894 | 0.81 | ALDH1A1 (0.43) | ALDH1A1KDM4ENPC1TP53HPGD | |
| SCHEMBL2642321 | 0.77 | PTGS2 (0.43) | KDM4ENPC1RAB9APTGS1PTGS2 | |
| SCHEMBL2642323 | 0.77 | PTGS2 (0.43) | KDM4ENPC1RAB9APTGS1PTGS2 | |
| SCHEMBL6972926 | 0.71 | ALDH1A1 (0.59) | ALDH1A1KDM4ENPC1TP53HPGD | |
| SCHEMBL27467646 | 0.65 | KCNH2 (0.46) | SLC6A3SLC6A2SLC6A4PTGS2FFAR1 | |
| SCHEMBL27502236 | 0.65 | KCNH2 (0.46) | SLC6A3SLC6A2SLC6A4PTGS2FFAR1 | |
| SCHEMBL10491773 | 0.65 | SLC6A3 (0.43) | KDM4EHPGDMAPTSLC6A3SLC6A2 | |
| SCHEMBL10491776 | 0.65 | SLC6A3 (0.43) | KDM4EHPGDMAPTSLC6A3SLC6A2 | |
| SCHEMBL27558086 | 0.65 | GCK (0.44) | SLC6A3SLC6A2SLC6A4FFAR1 | |
| SCHEMBL15078047 | 0.64 | ALDH1A1 (0.72) | ALDH1A1KDM4ENPC1TP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1329386-C | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-01 | — | — | CN | disclosed |
| CN-1649859-A | Substituted phenylacetamides and their use as glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-08-03 | — | — | CN | disclosed |