Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 5/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27346903 | 0.85 | KDM4E (0.45) | ALDH1A1KDM4ETSHRSMN1; SMN2HTT | |
| SCHEMBL6157293 | 0.80 | TSHR (0.60) | ALDH1A1KDM4ETSHRSMN1; SMN2MEN1 | |
| SCHEMBL27643364 | 0.79 | ALDH1A1 (0.44) | ALDH1A1KDM4ETSHRSMN1; SMN2HTT | |
| SCHEMBL28014587 | 0.76 | KMT2A (0.45) | ALDH1A1KDM4ETSHRSMN1; SMN2MEN1 | |
| SCHEMBL4277651 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KDM4EHTTMEN1LMNA | |
| SCHEMBL11079398 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KDM4ESMN1; SMN2HTTMEN1 | |
| SCHEMBL10585791 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KDM4EHTTMEN1LMNA | |
| SCHEMBL2358800 | 0.74 | GAA (0.52) | ALDH1A1KDM4ETSHRSMN1; SMN2HTT | |
| SCHEMBL27597874 | 0.74 | CA12 (0.42) | ALDH1A1KDM4ETSHRSMN1; SMN2HTT | |
| SCHEMBL9002576 | 0.73 | CA2 (0.55) | ALDH1A1KDM4ESMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100475787-C | Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents | LILLY CO ELI (US) | 2009-04-08 | — | — | CN | disclosed |
| CN-1514824-A | Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents | — | 2004-07-21 | — | — | CN | disclosed |