Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17352360 | 0.69 | GLO1 (0.53) | ALDH1A1TSHRKDM4ELMNAPKM | |
| SCHEMBL5308895 | 0.67 | LMNA (0.42) | ALDH1A1TSHRMAPTLMNAKMT2A | |
| SCHEMBL19750866 | 0.62 | KDM4E (0.41) | ALDH1A1TSHRKDM4EMAPTHSD17B10 | |
| Biphenyl SCHEMBL5898513 | 0.60 | ALDH1A1 (0.53) | ALDH1A1TSHRKDM4EMAPTHPGD | |
| SCHEMBL822673 | 0.60 | PCSK9 (0.68) | ALDH1A1KDM4EMAPTKMT2AGAA | |
| Biphenyl SCHEMBL8192900 | 0.60 | ALDH1A1 (0.53) | ALDH1A1TSHRKDM4EMAPTHPGD | |
| Biphenyl SCHEMBL1147617 | 0.60 | ALDH1A1 (0.53) | ALDH1A1TSHRKDM4EMAPTHPGD | |
| Biphenyl SCHEMBL51202 | 0.60 | ALDH1A1 (0.53) | ALDH1A1TSHRKDM4EMAPTHPGD | |
| Biphenyl SCHEMBL10876569 | 0.60 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTHPGDL3MBTL1 | |
| SCHEMBL14929531 | 0.59 | PCSK9 (0.41) | ALDH1A1KDM4EMAPTPKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100450477-C | Novel pyrrole compound with blood fat and cholesterol reducing activity, preparation method thereof, pharmaceutical composition containing same and medical application thereof | CADILA HEALTHCARE LTD (IN) | 2009-01-14 | — | — | CN | disclosed |
| CN-1558758-A | Novel pyrrole compound with blood fat and cholesterol reducing activity, preparation method thereof, pharmaceutical composition containing same and medical application thereof | — | 2004-12-29 | — | — | CN | disclosed |