Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27628157 | 0.83 | EPHX1 (0.45) | EPHX1CNR2BACE1BACE2P4HTM | |
| SCHEMBL27486343 | 0.81 | PPARG (0.41) | EPHX1PPARGPPARACNR2CYP19A1 | |
| SCHEMBL27991442 | 0.81 | EPHX1 (0.58) | EPHX1PPARGPPARACNR2KDM4E | |
| SCHEMBL28752987 | 0.80 | ALDH1A1 (0.51) | EPHX1PPARGPPARACNR2ALDH1A1 | |
| SCHEMBL27757352 | 0.78 | LMNA (0.51) | PPARGPPARASLC6A3HTT | |
| SCHEMBL28151669 | 0.77 | EPHX1 (0.77) | EPHX1PPARGPPARACNR2KDM4E | |
| SCHEMBL10636338 | 0.74 | KDM4E (0.55) | PPARGPPARACNR2CYP19A1KDM4E | |
| SCHEMBL4664796 | 0.72 | PPARA (0.56) | EPHX1PPARGPPARAALDH1A1PTPN1 | |
| SCHEMBL27608800 | 0.72 | PPARG (0.41) | PPARGPPARACNR2CYP19A1KDM4E | |
| SCHEMBL9896517 | 0.72 | PTGS1 (0.57) | EPHX1PPARGPPARAALDH1A1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100357282-C | Isothiazole derivatives, process for the preparation thereof, and pharmaceutical composition including the same | CJ CORP (KR) | 2007-12-26 | — | — | CN | disclosed |
| CN-1705650-A | Isothiazole derivatives, process for preparing the same, and pharmaceutical composition comprising the same | CJ CORP (KR) | 2005-12-07 | — | — | CN | disclosed |