Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 4/20 | 0.49 |
| ▸ | KISS1R | Q969F8 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | QRFPR | Q96P65 | 3/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | FCER2 | P06734 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464498 | 0.94 | PSMB5 (0.49) | PSMB5KISS1R | |
| SCHEMBL5049036 | 0.90 | PSMB5 (0.46) | PSMB5KISS1R | |
| SCHEMBL3487862 | 0.88 | FAAH (0.44) | PSMB5QRFPRMMP1 | |
| SCHEMBL5554051 | 0.84 | ACE (0.48) | OPRK1 | |
| SCHEMBL12057882 | 0.82 | PSMB5 (0.56) | PSMB5KISS1ROPRM1OPRD1OPRK1 | |
| SCHEMBL12243936 | 0.82 | PSMB5 (0.56) | PSMB5KISS1ROPRM1OPRD1OPRK1 | |
| SCHEMBL5037375 | 0.80 | PSMB5 (0.44) | PSMB5KISS1R | |
| SCHEMBL7053513 | 0.80 | NMUR2 (0.47) | OPRM1OPRD1 | |
| SCHEMBL2762308 | 0.77 | FAAH (0.42) | PSMB5MMP1 | |
| SCHEMBL23330990 | 0.76 | KISS1R (0.62) | PSMB5KISS1ROPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724381-B2 | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2017-08-08 | — | — | US | disclosed |
| US-20170049849-A9 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2017-02-23 | — | — | US | disclosed |
| US-20150031605-A1 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | UNIV TULANE (US) | 2015-01-29 | — | — | US | disclosed |
| US-8883721-B2 | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof | MCGILL UNIVERSITY (CA) | 2014-11-11 | — | — | US | disclosed |
| US-20120135918-A1 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | MCGILL UNIVERSITY (CA) | 2012-05-31 | — | — | US | disclosed |
| WO-2010132580-A2 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2010-11-18 | — | — | WO | disclosed |
| US-20080269116-A1 | Methods of Inhibiting Proinflammatory Cytokine Expression Using Ghrelin | TAUB DENNIS D | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135918-A1 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | GHSR, GIPR, GHRHR | PSMB5 1770/4885KISS1R 431/4885OPRM1 2765/4885 |
| US-20150031605-A1 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | GHSR, GIPR, GHRHR | PSMB5 1769/4885KISS1R 418/4885OPRM1 2663/4885 |
| US-20170049849-A9 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | GHSR, GIPR, GHRHR | PSMB5 1769/4885KISS1R 418/4885OPRM1 2663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.