Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678045 | 0.85 | MAPT (0.50) | MAPTALDH1A1ENPP2KMT2AMEN1 | |
| SCHEMBL28025616 | 0.83 | HTT (0.53) | MAPTALDH1A1HTTENPP2KMT2A | |
| SCHEMBL27716544 | 0.76 | MAPT (0.42) | MAPTALDH1A1HTTKMT2AMEN1 | |
| Tert-Butyl Formate SCHEMBL27615545 | 0.76 | HTR6 (0.48) | MAPTHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL28752031 | 0.73 | ALDH1A1 (0.69) | MAPTALDH1A1HTTKMT2AMEN1 | |
| SCHEMBL27737427 | 0.73 | MAPT (0.42) | MAPTALDH1A1KMT2AMEN1NPSR1 | |
| SCHEMBL27388637 | 0.71 | HTR1A (0.55) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL6276534 | 0.71 | MEN1 (0.47) | MAPTHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6677643 | 0.71 | ALDH1A1 (0.47) | MAPTHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL13100981 | 0.71 | MAPT (0.48) | MAPTALDH1A1HTTENPP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100390157-C | Substituted benzo (58743) | HOFFMANN LA ROCHE (CH) | 2008-05-28 | — | — | CN | disclosed |
| CN-1723205-A | Substituted benzoxazinones and uses thereof | HOFFMANN LA ROCHE (CH) | 2006-01-18 | — | — | CN | disclosed |