Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678045 | 0.78 | MAPT (0.50) | MAPTMEN1KMT2A | |
| Tert-Butyl Formate SCHEMBL27716545 | 0.76 | HTR6 (0.50) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27615544 | 0.76 | MAPT (0.43) | HTR1AADRA1DADRA1AADRA1BMAPT | |
| SCHEMBL24130664 | 0.74 | HTR3A (0.50) | HTR6HTR1AMAPTHTR7 | |
| Tert-Butyl Formate SCHEMBL27737428 | 0.73 | MAPT (0.41) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| Tert-Butyl Formate SCHEMBL28752032 | 0.73 | ALDH1A1 (0.56) | MAPTMEN1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL30481714 | 0.73 | MAPT (0.51) | HTR6HTR1AMAPTHTR7 | |
| SCHEMBL15819302 | 0.72 | HTR1A (0.53) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| Tert-Butyl Formate SCHEMBL27703771 | 0.71 | MAPT (0.51) | HTR6MAPTMEN1KMT2APOLB | |
| Tert-Butyl Formate SCHEMBL27770095 | 0.71 | MAPT (0.43) | HTR6MAPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100390157-C | Substituted benzo (58743) | HOFFMANN LA ROCHE (CH) | 2008-05-28 | — | — | CN | disclosed |
| CN-1723205-A | Substituted benzoxazinones and uses thereof | HOFFMANN LA ROCHE (CH) | 2006-01-18 | — | — | CN | disclosed |