Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1150467 | 0.91 | THRB (0.52) | THRBMEN1KMT2ACCNCCDK8 | |
| SCHEMBL27616343 | 0.81 | KCNE1 (0.54) | MEN1KMT2APOLBSMN1; SMN2TP53 | |
| SCHEMBL1150935 | 0.77 | ROCK2 (0.52) | THRBKDM4ESMN1; SMN2TP53MAPT | |
| SCHEMBL1150113 | 0.77 | ROCK2 (0.46) | KDM4ESMN1; SMN2TP53MAPTALDH1A1 | |
| SCHEMBL1150469 | 0.76 | ROCK2 (0.47) | MEN1KMT2AKDM4ESMN1; SMN2TP53 | |
| SCHEMBL6017840 | 0.75 | ALDH1A1 (0.55) | MEN1KMT2APOLBALDH1A1L3MBTL1 | |
| SCHEMBL6017760 | 0.74 | SMN1; SMN2 (0.57) | MEN1KMT2APOLBSMN1; SMN2MAPT | |
| SCHEMBL1150462 | 0.74 | LMNA (0.46) | THRBMEN1KMT2APOLBTP53 | |
| SCHEMBL14260085 | 0.74 | KMT2A (0.53) | MEN1KMT2APOLBSMN1; SMN2TP53 | |
| SCHEMBL5123540 | 0.73 | THRB (0.49) | THRBMEN1KMT2ACCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1700918-B | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | ANGELETTI P IST RICHERCHE BIO | 2011-06-08 | — | — | CN | claimed |
| CN-1700918-A | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | ANGELETTI P IST RICHERCHE BIO (IT) | 2005-11-23 | — | — | CN | claimed |
| CN-1700918-B | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | ANGELETTI P IST RICHERCHE BIO | 2011-06-08 | — | — | CN | disclosed |
| CN-1700918-A | N-substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase | ANGELETTI P IST RICHERCHE BIO (IT) | 2005-11-23 | — | — | CN | disclosed |