Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5042192 | 0.91 | CCNE1 (0.46) | CCNE1CDK2CDK5RAB9ANPC1 | |
| SCHEMBL27637763 | 0.82 | AURKA (0.50) | CCNE1CDK2CDK5SMN1; SMN2L3MBTL1 | |
| SCHEMBL27618657 | 0.77 | RAB9A (0.40) | RAB9ANPC1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL27618606 | 0.76 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL4365913 | 0.74 | GAA (0.53) | RAB9ANPC1SMN1; SMN2POLBLMNA | |
| SCHEMBL5045023 | 0.73 | AURKA (0.52) | CCNE1CDK2CDK5SMN1; SMN2L3MBTL1 | |
| SCHEMBL661640 | 0.71 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2POLBMAPT | |
| SCHEMBL5046778 | 0.69 | CCNE1 (0.45) | CCNE1CDK2CDK5RAB9ANPC1 | |
| SCHEMBL5045601 | 0.68 | ALDH1A1 (0.45) | CCNE1CDK2CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL27739667 | 0.68 | FPR3 (0.47) | CCNE1CDK2CDK5RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1753889-A | Quinazoline compounds | ASTRAZENECA AB (SE) | 2006-03-29 | — | — | CN | disclosed |