Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27618658 | 0.91 | CCNE1 (0.41) | CCNE1CDK2CDK5NPC1SMN1; SMN2 | |
| SCHEMBL5045023 | 0.81 | AURKA (0.52) | CCNE1CDK2CDK5SMN1; SMN2L3MBTL1 | |
| SCHEMBL27618657 | 0.80 | RAB9A (0.40) | NPC1SMN1; SMN2RAB9AL3MBTL1POLB | |
| SCHEMBL27618606 | 0.78 | RAB9A (0.42) | NPC1SMN1; SMN2RAB9AL3MBTL1POLB | |
| SCHEMBL5045601 | 0.78 | ALDH1A1 (0.45) | CCNE1CDK2CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL14095608 | 0.77 | ALDH1A1 (0.53) | CCNE1CDK2CDK5SMN1; SMN2L3MBTL1 | |
| SCHEMBL661640 | 0.76 | RAB9A (0.56) | NPC1SMN1; SMN2RAB9APOLBALDH1A1 | |
| SCHEMBL1031633 | 0.75 | SMN1; SMN2 (0.47) | CCNE1CDK2CDK5SMN1; SMN2MAPK1 | |
| SCHEMBL8834765 | 0.75 | CCNE1 (0.52) | CCNE1CDK2CDK5SMN1; SMN2ALDH1A1 | |
| SCHEMBL1939044 | 0.74 | CA1 (0.45) | CCNE1CDK2CDK5SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407946-B2 | Quinazoline compounds | ASTRAZENECA AB (SE) | 2008-08-05 | — | — | US | disclosed |
| CN-1753889-A | Quinazoline compounds | ASTRAZENECA AB (SE) | 2006-03-29 | — | — | CN | disclosed |
| US-20060058523-A1 | Quinazoline compounds | ASTRAZENECA AB (SE) | 2006-03-16 | — | — | US | disclosed |
| EP-1575946-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058752-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058523-A1 | Quinazoline compounds | NDUFS5, ABL1, NDUFS7 | CCNE1 1042/4885CDK2 138/4885CDK5 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.