Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27814336 | 0.89 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNATDP1SMN1; SMN2 | |
| Quinoline SCHEMBL27860538 | 0.88 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNATDP1SMN1; SMN2 | |
| Quinoline SCHEMBL27472061 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL2761059 | 0.84 | CYP2D6 (0.44) | ALDH1A1KDM4ELMNAMAPTTDP1 | |
| Quinoline SCHEMBL28849626 | 0.84 | ALDH1A1 (0.38) | ALDH1A1KDM4ELMNASMN1; SMN2POLB | |
| Quinoline SCHEMBL27925785 | 0.83 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTSMN1; SMN2HTT | |
| Quinoline SCHEMBL31120798 | 0.82 | ALDH1A1 (0.70) | ALDH1A1KDM4ELMNAMAPTTDP1 | |
| Quinoline SCHEMBL1405722 | 0.82 | ALDH1A1 (0.70) | ALDH1A1KDM4ELMNAMAPTTDP1 | |
| Quinoline SCHEMBL28084990 | 0.80 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPTSMN1; SMN2HTT | |
| Quinoline SCHEMBL27749698 | 0.80 | ALDH1A1 (0.45) | ALDH1A1KDM4ELMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1681878-A | Polymer composition formed from polymer and ionic liquid | DEGUSSA (DE) | 2005-10-12 | — | — | CN | disclosed |