Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.50 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3052008 | 0.79 | ALDH1A1 (0.40) | ALDH1A1MAPK1MAPTHPGDMEN1 | |
| SCHEMBL1251888 | 0.78 | ALDH1A1 (0.55) | ITGB1ITGA5VCAM1ALDH1A1TTR | |
| SCHEMBL4605109 | 0.78 | VCAM1 (0.62) | ITGB1ITGA5VCAM1ALDH1A1TTR | |
| SCHEMBL332714 | 0.77 | VCAM1 (0.63) | ITGB1ITGA5VCAM1ALDH1A1TTR | |
| SCHEMBL8626465 | 0.76 | TTR (0.62) | ITGB1ITGA5VCAM1ALDH1A1TTR | |
| SCHEMBL4604303 | 0.76 | VCAM1 (0.81) | ITGB1ITGA5VCAM1ALDH1A1TTR | |
| SCHEMBL9307787 | 0.76 | VCAM1 (0.81) | ITGB1ITGA5VCAM1ALDH1A1TTR | |
| SCHEMBL10951198 | 0.74 | ALDH1A1 (0.56) | ITGB1ITGA5VCAM1ALDH1A1MAPK1 | |
| SCHEMBL10951890 | 0.73 | ALDH1A1 (0.63) | ITGB1ITGA5VCAM1ALDH1A1TTR | |
| SCHEMBL28801592 | 0.73 | MAPT (0.44) | ALDH1A1MAPK1LMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101284819-A | Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient | ONO PHARMACEUTICAL CO (JP) | 2008-10-15 | — | — | CN | disclosed |
| CN-100348587-C | Fused pyridazine derivative compounds and drugs containing these compounds as active ingredients | ONO PHARMACEUTICAL CO (JP) | 2007-11-14 | — | — | CN | disclosed |
| CN-1646499-A | Fused pyridazine derivative compounds and drugs containing these compounds as active ingredients | ONO PHARMACEUTICAL CO (JP) | 2005-07-27 | — | — | CN | disclosed |