Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.62 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RARB | P10826 | 6/20 | 0.55 |
| ▸ | MMP12 | P39900 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1951510 | 0.91 | FFAR1 (0.54) | FFAR1MCL1ABCC4LMNAGAA | |
| Bicarbonate SCHEMBL27623751 | 0.88 | RARB (0.71) | FFAR1RARBHPGDMAPTMEN1 | |
| Boric Acid SCHEMBL31374401 | 0.88 | LPL (0.55) | FFAR1MCL1ABCC4LMNAGAA | |
| SCHEMBL28842020 | 0.88 | FFAR1 (0.52) | FFAR1MCL1ABCC4LMNAGAA | |
| Ethyne SCHEMBL28568325 | 0.87 | FFAR1 (0.50) | FFAR1MCL1ABCC4LMNAGAA | |
| Bicarbonate SCHEMBL27969158 | 0.87 | ALDH1A1 (0.58) | FFAR1SMN1; SMN2L3MBTL1HPGDMAPT | |
| Bicarbonate SCHEMBL27623722 | 0.86 | RARB (0.72) | FFAR1RARBHPGDMAPTMEN1 | |
| Bicarbonate SCHEMBL27817579 | 0.85 | RARB (0.73) | LMNATSHRPTGS1RARBMAPT | |
| Bicarbonate SCHEMBL27643232 | 0.85 | RARB (0.73) | LMNATSHRPTGS1RARBMAPT | |
| SCHEMBL17473011 | 0.84 | THRB (0.55) | FFAR1MCL1RARBMMP12SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108290820-A | Method for recovering aromatic alcohol from melt polymerization and system for recovering same | 沙特基础工业全球技术有限公司 | 2018-07-17 | — | — | CN | disclosed |
| CN-105189604-B | The production of makrolon with limited metal residue | 沙特基础全球技术有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-107075103-A | The method that makrolon is manufactured using liquid alcohol/ketone mixtures | 沙特基础工业全球技术有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-104136508-B | Prepare for the method with low stress and the film of optical property in photoelectric device | 科思创德国股份有限公司 | 2017-07-21 | — | — | CN | disclosed |
| CN-105189604-A | Production of a polycarbonate with limited metal residuals | SABIC INNOVATIVE PLASTICS IP | 2015-12-23 | — | — | CN | disclosed |
| CN-104231254-A | Process for the manufacture of polycarbonate compositions | SABIC INNOVATIVE PLASTICS IP | 2014-12-24 | — | — | CN | disclosed |
| CN-104136508-A | Process for the production of low stress and optical quality film for use in opto-electronic devices | BAYER MATERIALSCIENCE AG | 2014-11-05 | — | — | CN | disclosed |
| CN-103748259-A | A process for multi-layer continuous roll-to-roll coating | BAYER SOUTH EAST ASIA PTE LTD | 2014-04-23 | — | — | CN | disclosed |
| CN-101429277-B | Method for producing polycarbonate by the melt transesterification method | BAYER MATERIALSCIENCE AG | 2013-03-27 | — | — | CN | disclosed |
| CN-102442910-A | Process for preparing diaryl carbonates from dialkyl carbonates | BAYER MATERIALSCIENCE AG | 2012-05-09 | — | — | CN | disclosed |
| CN-1712450-B | Thermally stable polycarbonate compositions | BAYER MATERIALSCIENCE AG | 2010-05-26 | — | — | CN | disclosed |
| CN-101429277-A | Method for producing polycarbonate by the melt transesterification method | BAYER MATERIALSCIENCE AG (DE) | 2009-05-13 | — | — | CN | disclosed |
| CN-1712450-A | Thermally stable polycarbonate compositions | BAYER MATERIALSCIENCE AG (DE) | 2005-12-28 | — | — | CN | disclosed |