Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4252110 | 0.78 | ALDH1A1 (0.47) | ALDH1A1NPSR1HTTUSP2ALOX15 | |
| SCHEMBL27430260 | 0.78 | ALDH1A1 (0.50) | ALDH1A1NPSR1HTTUSP2ALOX15 | |
| SCHEMBL4878508 | 0.75 | AKR1C3 (0.71) | ALDH1A1NPSR1HTTUSP2ALOX15 | |
| SCHEMBL12128211 | 0.74 | HTT (0.51) | ALDH1A1NPSR1HTTUSP2ALOX15 | |
| SCHEMBL29174588 | 0.74 | ALDH1A1 (0.44) | ALDH1A1NPSR1HTTUSP2ALOX15 | |
| SCHEMBL23012370 | 0.73 | AKR1C3 (0.52) | ALDH1A1NPSR1PKMKMT2AMAPT | |
| SCHEMBL24254274 | 0.73 | PKM (0.58) | ALDH1A1NPSR1HTTUSP2ALOX15 | |
| SCHEMBL12128393 | 0.69 | HTT (0.47) | ALDH1A1NPSR1HTTUSP2ALOX15 | |
| SCHEMBL4254051 | 0.69 | POLB (0.54) | ALDH1A1NPSR1HTTPKMKMT2A | |
| SCHEMBL568658 | 0.69 | ALDH1A1 (0.51) | ALDH1A1NPSR1HTTUSP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120839-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB | 2010-05-13 | — | — | US | disclosed |
| CN-101687861-A | Pyrazoles useful in the treatment of inflammation | BIOLIPOX AB | 2010-03-31 | — | — | CN | disclosed |
| EP-2146983-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2010-01-27 | — | — | EP | disclosed |
| US-20090143440-A1 | Pyrazoles Useful in the Treatment of Inflammation | BIOLIPOX AB (SE) | 2009-06-04 | — | — | US | disclosed |
| US-20090143455-A1 | Pyrazoles Useful in the Treatment of Inflammation | BIOLIPOX AB (SE) | 2009-06-04 | — | — | US | disclosed |
| CN-101331118-A | Pyrazoles useful in the treatment of inflammation | BIOLIPOX AB (SE) | 2008-12-24 | — | — | CN | disclosed |
| WO-2008129280-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2008-10-30 | — | — | WO | disclosed |
| EP-1943241-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2008-07-16 | — | — | EP | disclosed |
| EP-1937645-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| US-20070225318-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | BIOLIPOX AB (SE) | 2007-09-27 | — | — | US | disclosed |
| EP-1794145-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007051981-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007045868-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2007-04-26 | — | — | WO | disclosed |
| WO-2006032851-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225318-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | ALOX15, ALOX15B, ALOX12 | ALDH1A1 306/4885NPSR1 1506/4885HTT 3645/4885 |
| US-20100120839-A1 | PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION | ALOX15, ALOX12, ALOX15B | ALDH1A1 198/4885NPSR1 996/4885HTT 4094/4885 |
| US-20090143440-A1 | Pyrazoles Useful in the Treatment of Inflammation | ALOX15, ALOX12, ALOX15B | ALDH1A1 654/4885NPSR1 782/4885HTT 4266/4885 |
| US-20090143455-A1 | Pyrazoles Useful in the Treatment of Inflammation | ALOX15, ALOX12, ALOX15B | ALDH1A1 706/4885NPSR1 801/4885HTT 4098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.