Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201491 | 0.81 | TSHR (0.50) | TSHRMAPTSMN1; SMN2KDM4EPOLB | |
| SCHEMBL6201649 | 0.79 | ALDH1A1 (0.43) | TSHRRAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6202063 | 0.78 | MDM2 (0.46) | MAPTKDM4ECYP1A2CYP2C9HPGD | |
| SCHEMBL6203245 | 0.70 | PSMB5 (0.44) | RAB9AKDM4EHPGD | |
| SCHEMBL27628035 | 0.66 | POLB (0.59) | RAB9ANPC1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL7363501 | 0.65 | KDM4E (0.50) | KDM4ELMNA | |
| SCHEMBL1127590 | 0.65 | KMT2A (0.46) | TSHRRAB9ANPC1POLBCYP1A2 | |
| SCHEMBL6201072 | 0.65 | TSHR (0.48) | TSHRMAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9048735 | 0.65 | POLB (0.61) | RAB9AMAPTNPC1SMN1; SMN2KDM4E | |
| SCHEMBL3373228 | 0.64 | KMT2A (0.45) | TSHRRAB9ANPC1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |