Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 11/20 | 0.50 |
| ▸ | MET | P08581 | 6/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27630181 | 0.88 | MET (0.51) | FYNMETJAK2MAP4K3ROS1 | |
| SCHEMBL5480975 | 0.86 | MET (0.53) | FYNMETJAK2MAP4K3ALK | |
| SCHEMBL487679 | 0.84 | MET (0.57) | FYNMETJAK2MAP4K3ALK | |
| SCHEMBL487842 | 0.81 | JAK2 (0.60) | FYNMETJAK2MAP4K3 | |
| SCHEMBL30453168 | 0.81 | JAK2 (0.60) | FYNMETJAK2MAP4K3 | |
| SCHEMBL5480970 | 0.80 | MET (0.53) | FYNMETJAK2MAP4K3ALK | |
| SCHEMBL488121 | 0.80 | MAP4K4 (0.54) | METJAK2MAP4K3 | |
| SCHEMBL30453459 | 0.80 | MAP4K4 (0.54) | METJAK2MAP4K3 | |
| SCHEMBL27630135 | 0.80 | MET (0.64) | FYNMETJAK2MAP4K3 | |
| SCHEMBL3122066 | 0.80 | MET (0.56) | FYNMETJAK2MAP4K3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | claimed |
| CN-1777427-A | Aminoheteroaryl compounds as protein kinase inhibitors | SUGEN INC (US) | 2006-05-24 | — | — | CN | disclosed |