SCHEMBL2763236

SCHEMBL2763236

O=c1c2ccccc2oc2ccc(Cl)nc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.55
KDM4E B2RXH2 2/20 0.55
ALDH1A1 P00352 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
MAPT P10636 2/20 0.55
GLA P06280 1/20 0.55
CYP3A4 P08684 1/20 0.55
HPGD P15428 1/20 0.55
PGAM1 P18669 1/20 0.55
CASP1 P29466 1/20 0.55
CASP7 P55210 1/20 0.55
HSD17B10 Q99714 1/20 0.55
ADORA3 P0DMS8 1/20 0.45
TTR P02766 1/20 0.43
NPC1 O15118 3/20 0.42
RAB9A P51151 2/20 0.42
POLB P06746 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
AKR1B1 P15121 1/20 0.41
RET P07949 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24055807 0.86 SMN1; SMN2 (0.51) MAOAKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL544963 0.83 MAOA (0.55) MAOAKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL2930770 0.80 MAOA (0.55) MAOAKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL6845285 0.80 MAPT (0.38) MAOAKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL570679 0.80 KMT2A (0.44) KDM4ESMN1; SMN2HSD17B10KMT2A
SCHEMBL22171892 0.78 KDM4E (0.60) MAOAKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL1375648 0.76 MAOA (0.50) MAOAKDM4EALDH1A1SMN1; SMN2MAPT
SCHEMBL2763806 0.76 PON1 (0.47) KDM4EALDH1A1SMN1; SMN2MAPTHPGD
SCHEMBL15631657 0.75 CYP3A4 (0.34) ALDH1A1SMN1; SMN2MAPTCYP3A4KMT2A
SCHEMBL3709991 0.74 KDM4E (0.48) MAOAKDM4EALDH1A1SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100204467-A1 LANTHANIDE (III) ION COMPLEXING COMPOUNDS, LUMINESCENT LANTHANIDE (III) ION COMPLEXES AND USE THEREOF AS FLUORESCENT LABELS CIS BIO INTERNATIONAL (FR) 2010-08-12 US disclosed
WO-2010084090-A1 PYRIDYL-AZA(THIO)XANTHONE SENSITIZER COMPRISING LANTHANIDE(III) ION COMPLEXING COMPOUNDS, THEIR LUMINESCENT LANTHANIDE (III) ION COMPLEXES AND USE THEREOF AS FLUORESCENT LABELS. CIS BIO INTERNATIONAL (FR) 2010-07-29 WO disclosed
EP-2176267-A1 LANTHANIDE (III) ION COMPLEXING COMPOUNDS, LUMINESCENT LANTHANIDE (III) ION COMPLEXES AND USE THEREOF AS FLUORESCENT LABELS CIS bio international (FR) 2010-04-21 EP disclosed
WO-2009010580-A1 LANTHANIDE (III) ION COMPLEXING COMPOUNDS, LUMINESCENT LANTHANIDE (III) ION COMPLEXES AND USE THEREOF AS FLUORESCENT LABELS CIS BIO INTERNATIONAL (FR) 2009-01-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100204467-A1 LANTHANIDE (III) ION COMPLEXING COMPOUNDS, LUMINESCENT LANTHANIDE (III) ION COMPLEXES AND USE THEREOF AS FLUORESCENT LABELS CBR3, CLIC4, GLRA3 MAOA 2403/4885KDM4E 2912/4885ALDH1A1 2531/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.