Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL570679 | 0.82 | KMT2A (0.44) | SMN1; SMN2KDM4EKMT2ATBK1CDC7 | |
| SCHEMBL2763236 | 0.80 | MAOA (0.55) | MAPTNPC1RAB9ASMN1; SMN2TTR | |
| SCHEMBL2763806 | 0.78 | PON1 (0.47) | MAPTNPC1RAB9ASMN1; SMN2GFER | |
| SCHEMBL15631657 | 0.76 | CYP3A4 (0.34) | MAPTSMN1; SMN2ALDH1A1KMT2ADYRK1A | |
| SCHEMBL6845282 | 0.76 | KDM4E (0.43) | MAPTNPC1RAB9ASMN1; SMN2GFER | |
| SCHEMBL10285124 | 0.71 | TTR (0.35) | MAPTNPC1RAB9ASMN1; SMN2GFER | |
| SCHEMBL14684135 | 0.70 | MAOA (0.67) | MAPTNPC1RAB9ASMN1; SMN2GFER | |
| SCHEMBL10123835 | 0.70 | AHR (0.41) | MAPTNPC1RAB9ASMN1; SMN2GFER | |
| SCHEMBL6845255 | 0.69 | NPC1 (0.47) | MAPTNPC1RAB9ASMN1; SMN2GFER | |
| SCHEMBL24055807 | 0.68 | SMN1; SMN2 (0.51) | MAPTNPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |