Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27762022 | 0.81 | ADORA2B (0.44) | ADORA2BALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL27811680 | 0.81 | ADORA2B (0.44) | ADORA2BALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL20547480 | 0.79 | MEN1 (0.40) | ADORA2BALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL11615550 | 0.77 | GLA (0.47) | ADORA2BALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL25642259 | 0.69 | ADORA2B (0.48) | ADORA2BALDH1A1MEN1KMT2ASLC18A3 | |
| SCHEMBL28735251 | 0.67 | ADORA2B (0.49) | ADORA2BALDH1A1MEN1KMT2ASLC18A3 | |
| SCHEMBL27782413 | 0.67 | CYP11B1 (0.40) | ADORA2BCYP11B1CYP11B2 | |
| SCHEMBL13587959 | 0.67 | ALDH1A1 (0.50) | ADORA2BALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL502049 | 0.66 | SMN1; SMN2 (0.66) | MEN1KMT2ASMN1; SMN2TSHRMAPT | |
| SCHEMBL501640 | 0.66 | TBXAS1 (0.54) | ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100404535-C | Organic compounds useful as medicaments for the treatment of aldosterone-mediated conditions | NOVARTIS AG (CH) | 2008-07-23 | — | — | CN | disclosed |
| CN-1688583-A | Organic compounds as agents for the treatment of aldosterone mediated conditions | NOVARTIS AG (CH) | 2005-10-26 | — | — | CN | disclosed |