Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.36 |
| ▸ | HTR6 | P50406 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29024319 | 0.88 | CA2 (0.36) | HTTHRH4HTR6ALDH1A1TSHR | |
| SCHEMBL28759659 | 0.83 | HTT (0.33) | HTT | |
| SCHEMBL28252743 | 0.80 | HTT (0.33) | HTTALDH1A1HCRTR2 | |
| SCHEMBL7067658 | 0.78 | ALDH1A1 (0.41) | HTTHTR6ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL28966886 | 0.77 | HTT (0.37) | HTTALDH1A1TDP1 | |
| SCHEMBL28645585 | 0.77 | PTPN1 (0.40) | HTTALDH1A1TSHRSMN1; SMN2TDP1 | |
| SCHEMBL29104732 | 0.77 | CA1 (0.41) | HTTALDH1A1TSHRTDP1 | |
| SCHEMBL28211544 | 0.76 | KMT2A (0.38) | HTTALDH1A1TSHR | |
| SCHEMBL8788235 | 0.75 | CYP2D6 (0.37) | HTTALDH1A1HCRTR2TSHR | |
| SCHEMBL6754204 | 0.74 | LMNA (0.41) | HTTALDH1A1TSHRSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602813-A | Heteroaryl hydroxypyrimidinone as apj receptor agonist | 百时美施贵宝公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-103664973-A | Spiro-oxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2014-03-26 | — | — | CN | disclosed |
| CN-102600162-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2012-07-25 | — | — | CN | disclosed |
| CN-102256983-A | Spirooxindole compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2011-11-23 | — | — | CN | disclosed |
| CN-101980709-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2011-02-23 | — | — | CN | disclosed |
| CN-101669952-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC | 2010-03-17 | — | — | CN | disclosed |
| CN-100558713-C | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2009-11-11 | — | — | CN | disclosed |
| CN-101160289-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-04-09 | — | — | CN | disclosed |
| CN-101090724-A | Pyridine derivatives for inhibiting human stearoyl-CoA desaturase | XENON PHARMACEUTICALS INC (CA) | 2007-12-19 | — | — | CN | disclosed |
| CN-1829698-A | Pyridazine derivatives and their use as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2006-09-06 | — | — | CN | disclosed |