Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP9X | Q93008 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310644 | 0.83 | TSHR (0.44) | HTTLMNATSHRALDH1A1MAPT | |
| SCHEMBL28311125 | 0.83 | ALDH1A1 (0.43) | HTTLMNATSHRALDH1A1HPGD | |
| SCHEMBL28635566 | 0.81 | BRD4 (0.42) | LMNABRD4 | |
| SCHEMBL28651157 | 0.81 | RXRA (0.35) | HTTLMNAPDE4APDE4BTSHR | |
| SCHEMBL6204947 | 0.79 | LMNA (0.37) | HTTLMNATSHRALDH1A1HPGD | |
| SCHEMBL27633952 | 0.77 | HTT (0.39) | HTTTSHRALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL28488096 | 0.77 | TSHR (0.39) | HTTLMNATSHRALDH1A1MAPT | |
| SCHEMBL27511647 | 0.77 | HTT (0.44) | HTTLMNATSHRALDH1A1HSD17B10 | |
| SCHEMBL6421674 | 0.75 | NCF1 (0.36) | HTTLMNATSHRALDH1A1MAPT | |
| SCHEMBL27828724 | 0.75 | CA12 (0.40) | LMNATSHRALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113490670-B | Nitrogen-containing polycyclic condensed ring compound, pharmaceutical composition, preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-113490670-A | Nitrogen-containing polycyclic fused ring compound, and pharmaceutical composition, preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2021-10-08 | — | — | CN | disclosed |