SCHEMBL28211544

SCHEMBL28211544

CCOS(=O)(=O)c1ccc(C)c(F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.38
BRD1 O95696 1/20 0.38
BRPF1 P55201 1/20 0.38
ALDH3A1 P30838 1/20 0.38
HTT P42858 3/20 0.38
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA4 P22748 1/20 0.37
CA6 P23280 1/20 0.37
CA5A P35218 1/20 0.37
CA7 P43166 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
CA5B Q9Y2D0 1/20 0.37
PTGS2 P35354 2/20 0.36
ALDH1A1 P00352 3/20 0.36
TSHR P16473 3/20 0.36
USP2 O75604 1/20 0.36
TP53 P04637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10469065 0.81 CA12 (0.36) KMT2ABRD1BRPF1CA12CA1
SCHEMBL13290705 0.80 KMT2A (0.41) KMT2ABRD1BRPF1ALDH3A1CA12
SCHEMBL6262479 0.79 PTGS2 (0.44) KMT2AHTTPTGS2PTGS1LMNA
SCHEMBL12186138 0.78 GAA (0.44) BRD1BRPF1ALDH3A1HTTPTGS2
SCHEMBL5310644 0.78 TSHR (0.44) KMT2AHTTCA1CA2ALDH1A1
SCHEMBL28311125 0.78 ALDH1A1 (0.43) KMT2AHTTALDH1A1TSHRGAA
SCHEMBL6754204 0.78 LMNA (0.41) ALDH3A1HTTALDH1A1TSHRLMNA
SCHEMBL15152546 0.77 CA2 (0.37) KMT2ABRD1BRPF1CA2PTGS2
SCHEMBL28651157 0.76 RXRA (0.35) KMT2AHTTALDH1A1TSHRGAA
SCHEMBL4127590 0.76 KMT2A (0.38) KMT2ABRD1BRPF1ALDH3A1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110267949-A SGC stimulant 塞科里昂医疗股份有限公司 2019-09-20 CN disclosed
CN-107922407-A Respiratory Syncytial Virus(RSV) inhibitor 美迪维尔公司 2018-04-17 CN disclosed