SCHEMBL27634005

SCHEMBL27634005

NS(=O)(=O)c1sc(O)c(-c2ccccc2)c1S(=O)(=O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.41
CA2 P00918 10/20 0.38
CA1 P00915 8/20 0.38
CA12 O43570 5/20 0.38
CA9 Q16790 4/20 0.38
DAPK1 P53355 1/20 0.36
HTT P42858 1/20 0.35
CA4 P22748 4/20 0.34
CA5A P35218 3/20 0.34
CA5B Q9Y2D0 3/20 0.34
CA7 P43166 3/20 0.34
CA14 Q9ULX7 3/20 0.34
CA3 P07451 2/20 0.34
CA6 P23280 2/20 0.34
CA13 Q8N1Q1 2/20 0.34
PLA2G7 Q13093 1/20 0.34
TSHR P16473 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PTGS2 P35354 5/20 0.33
BACE1 P56817 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7640488 0.75 ALDH1A1 (0.46) L3MBTL1CA2CA1CA12CA9
SCHEMBL23433032 0.70 SMN1; SMN2 (0.43) CA2CA1DAPK1HTTTSHR
SCHEMBL28064687 0.70 SMN1; SMN2 (0.43) CA2CA1DAPK1HTTTSHR
SCHEMBL7640473 0.69 ALDH1A1 (0.49) L3MBTL1CA2CA1CA12CA9
SCHEMBL8367595 0.68 TNNI3 (0.41) DAPK1HTTTSHRSMN1; SMN2BACE1
SCHEMBL9177949 0.67 KDM4E (0.38) DAPK1HTTTSHRSMN1; SMN2BACE1
SCHEMBL28020176 0.66 HDAC4 (0.46) DAPK1TSHRSMN1; SMN2BACE1MEN1
SCHEMBL38659502 0.66 L3MBTL1 (0.42) L3MBTL1HTTTSHRSMN1; SMN2PTGS2
SCHEMBL31282188 0.66 CYP2D6 (0.42) DAPK1HTTTSHRSMN1; SMN2BACE1
Biphenyl SCHEMBL2765859 0.65 CA2 (0.61) CA2CA1CA12CA9HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102883709-A Combinations of preservative compositions for ophthalmic formulations ALLERGAN INC 2013-01-16 CN disclosed
CN-102883708-A Combinations of preservatives for ophthalmic compositions ALLERGAN INC 2013-01-16 CN disclosed
CN-100528139-C Preserved ophthalmic compositions ALLERGAN INC (US) 2009-08-19 CN disclosed
CN-1794973-A preservative composition for eyes ALLERGAN INC (US) 2006-06-28 CN disclosed