Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 2/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5169008 | 0.78 | MEN1 (0.51) | MEN1MAPK1KMT2A | |
| SCHEMBL21044072 | 0.76 | HDAC1 (0.39) | MEN1MAPK1KMT2AHDAC3HDAC4 | |
| SCHEMBL22869122 | 0.73 | PDE5A (0.38) | MEN1MAPK1KMT2AHDAC3HDAC4 | |
| SCHEMBL27851849 | 0.72 | ALDH1A1 (0.38) | MAPK1HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL22490785 | 0.72 | PDE5A (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL27930580 | 0.68 | OPRM1 (0.39) | HDAC4 | |
| SCHEMBL20640304 | 0.66 | MEN1 (0.50) | MEN1MAPK1KMT2A | |
| SCHEMBL27868888 | 0.65 | OPRM1 (0.41) | MAPK1HDAC1 | |
| SCHEMBL27851848 | 0.64 | MAPT (0.39) | MAPK1KMT2A | |
| SCHEMBL22869165 | 0.63 | MEN1 (0.70) | MEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1839114-A | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | CN | disclosed |