Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27617653 | 0.93 | AURKA (0.31) | AURKAKDRAURKBMMP2KIF11 | |
| SCHEMBL27617662 | 0.91 | NSD2 (0.34) | MMP2KIF11CASP3KCNH2BRD4 | |
| SCHEMBL27617898 | 0.90 | ESR1 (0.34) | NSD2 | |
| Bicarbonate SCHEMBL27698792 | 0.89 | NSD2 (0.36) | BRD4NSD2 | |
| SCHEMBL27617731 | 0.88 | RORC (0.32) | — | |
| SCHEMBL27617760 | 0.84 | PSEN1 (0.33) | KDRAURKBMMP2KIF11 | |
| SCHEMBL27636779 | 0.83 | PSEN1 (0.32) | NSD2 | |
| SCHEMBL27617633 | 0.80 | HSD11B1 (0.32) | — | |
| SCHEMBL27617590 | 0.79 | GPR3 (0.35) | — | |
| SCHEMBL5214670 | 0.79 | PSEN1 (0.44) | MMP2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1720231-A | Substituted dihydrophenanthridinesulfonamides | WYETH CORP (US) | 2006-01-11 | — | — | CN | claimed |
| CN-1720231-A | Substituted dihydrophenanthridinesulfonamides | WYETH CORP (US) | 2006-01-11 | — | — | CN | disclosed |