Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27617898 | 0.93 | ESR1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27617653 | 0.90 | AURKA (0.31) | GPR3TYRNSD2 | |
| SCHEMBL27617668 | 0.90 | GPR3 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27636773 | 0.88 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27617662 | 0.85 | NSD2 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27617633 | 0.85 | HSD11B1 (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Bicarbonate SCHEMBL27698792 | 0.84 | NSD2 (0.36) | NSD2 | |
| SCHEMBL27636685 | 0.83 | AURKA (0.31) | NSD2 | |
| SCHEMBL27617731 | 0.83 | RORC (0.32) | — | |
| SCHEMBL27617590 | 0.82 | GPR3 (0.35) | GPR3TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1720231-A | Substituted dihydrophenanthridinesulfonamides | WYETH CORP (US) | 2006-01-11 | — | — | CN | disclosed |