Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CTSB | P07858 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | AQP1 | P29972 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27622154 | 0.94 | MAOB (0.40) | MAOBAQP1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL5395923 | 0.87 | AQP1 (0.36) | HSD11B1MAOBAQP1 | |
| SCHEMBL20959847 | 0.84 | CTSK (0.52) | CTSLCTSBCTSK | |
| SCHEMBL6177617 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL25564130 | 0.72 | DRD2 (0.50) | HSD11B1SMN1; SMN2MAPT | |
| SCHEMBL11160297 | 0.72 | CYP2D6 (0.45) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9671117 | 0.72 | CTSL (0.33) | CTSLCTSBCTSK | |
| SCHEMBL25564307 | 0.71 | DRD2 (0.49) | HSD11B1SMN1; SMN2MAPT | |
| SCHEMBL25564309 | 0.71 | DRD2 (0.49) | HSD11B1SMN1; SMN2MAPT | |
| SCHEMBL25564223 | 0.71 | DRD2 (0.49) | HSD11B1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1990468-A | Pyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORP (US) | 2007-07-04 | — | — | CN | disclosed |
| CN-1990469-A | Pyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORP (US) | 2007-07-04 | — | — | CN | disclosed |
| CN-1723196-A | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORP (US) | 2006-01-18 | — | — | CN | disclosed |