Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.74 |
| ▸ | ARG2 | P78540 | 4/20 | 0.47 |
| ▸ | ARG1 | P05089 | 3/20 | 0.47 |
| ▸ | NOS2 | P35228 | 6/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL6561904 | 1.00 | GSR (0.74) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL28112654 | 0.98 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL28112652 | 0.98 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Ornithine Aketoglutarate SCHEMBL2178954 | 0.94 | GSR (0.64) | GSRARG2ARG1NOS2NOS1 | |
| Ornithine Aketoglutarate SCHEMBL6512486 | 0.93 | GSR (0.62) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL28520628 | 0.91 | GSR (0.77) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL5359221 | 0.89 | GSR (0.80) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL15053532 | 0.87 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL28554653 | 0.87 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL7573653 | 0.87 | GSR (0.77) | GSRARG2ARG1NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025129139-A1 | TRIBLOCK COPOLYMERS AND HYDROGELS THEREOF | VANDERBILT UNIVERSITY (US) | 2025-06-19 | — | — | WO | claimed |
| US-20240408027-A1 | HIGH DRUG LOADING POLYMERS | VANDERBILT UNIVERSITY | 2024-12-12 | — | — | US | claimed |
| WO-2023059833-A1 | HIGH DRUG LOADING POLYMERS | VANDERBILT UNIVERSITY (US) | 2023-04-13 | — | — | WO | claimed |
| WO-2025129139-A1 | TRIBLOCK COPOLYMERS AND HYDROGELS THEREOF | VANDERBILT UNIVERSITY (US) | 2025-06-19 | — | — | WO | disclosed |
| US-20240408027-A1 | HIGH DRUG LOADING POLYMERS | VANDERBILT UNIVERSITY | 2024-12-12 | — | — | US | disclosed |
| WO-2024196783-A1 | BIOENGINEERED COLON-SPECIFIC IMMUNE NICHE FOR THE TREATMENT OF ULCERATIVE COLITIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-09-26 | — | — | WO | disclosed |
| WO-2023059833-A1 | HIGH DRUG LOADING POLYMERS | VANDERBILT UNIVERSITY (US) | 2023-04-13 | — | — | WO | disclosed |
| CN-106267324-A | A kind of temperature response type macromolecule bio-medical adhesive and synthetic method thereof | 西北师范大学 | 2017-01-04 | — | — | CN | disclosed |
| CN-100588331-C | Method for reducing acrylamide formation in thermally processed foods | FRITO LAY NORTH AMERICA INC FO | 2010-02-10 | — | — | CN | disclosed |
| CN-101631475-A | Method for reducing acrylamide formation | FRITO LAY NORTH AMERICA INC | 2010-01-20 | — | — | CN | disclosed |
| CN-1753623-A | Method for reducing acrylamide formation in thermally processed foods | FRITO LAY NORTH AMERICA INC FO (US) | 2006-03-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240408027-A1 | HIGH DRUG LOADING POLYMERS | ABCB1, ABCB11, FCGR2A | GSR 2288/4885ARG2 3565/4885ARG1 4408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.