Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ATP4A | P20648 | 1/20 | 0.37 |
| ▸ | ATP4B | P51164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26459294 | 0.78 | MAPT (0.46) | ALDH1A1HTTKDM4EL3MBTL1NPC1 | |
| SCHEMBL27645709 | 0.76 | KDM4E (0.39) | ALDH1A1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL28318766 | 0.64 | NUDT1 (0.40) | LMNAALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL2875450 | 0.64 | CLK4 (0.42) | LMNAALDH1A1KDM4EL3MBTL1NPC1 | |
| SCHEMBL973230 | 0.63 | KMT2A (0.50) | ALDH1A1KDM4EL3MBTL1KMT2ANUDT1 | |
| SCHEMBL15716701 | 0.63 | PTGER1 (0.43) | LMNAALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL4000527 | 0.60 | KDM4E (0.52) | LMNAALDH1A1HTTKDM4EL3MBTL1 | |
| Fenclorim SCHEMBL20564320 | 0.58 | LMNA (0.73) | LMNAALDH1A1HTTKDM4EL3MBTL1 | |
| SCHEMBL8881198 | 0.58 | PCSK9 (0.45) | ALDH1A1KDM4EL3MBTL1KMT2ANUDT1 | |
| SCHEMBL23860768 | 0.57 | KDM4E (0.53) | LMNAALDH1A1HTTKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1913898-A | Substituted piperazines | CHEMOCENTRYX INC (US) | 2007-02-14 | — | — | CN | disclosed |