Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 4/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723774 | 0.82 | FAAH (0.55) | FAAHEPHX2NAMPT | |
| SCHEMBL27645813 | 0.75 | SCD5 (0.42) | MEN1KMT2AALDH1A1LMNAOPRM1 | |
| SCHEMBL27666948 | 0.68 | TRPV1 (0.45) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL27672087 | 0.68 | FKBP1A (0.50) | FAAHMEN1KMT2AALDH1A1 | |
| SCHEMBL7496835 | 0.67 | MEN1 (0.71) | MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7514728 | 0.67 | HDAC1 (0.64) | NPC1FAAHLMNACES1 | |
| SCHEMBL7502276 | 0.67 | TACR1 (0.48) | KDM1AMEN1KMT2AALDH1A1OPRM1 | |
| SCHEMBL6017226 | 0.65 | HDAC1 (0.66) | FAAHMEN1KMT2ALMNACES1 | |
| SCHEMBL21644362 | 0.65 | TACR1 (0.52) | KDM1AOPRD1OPRK1 | |
| SCHEMBL17117404 | 0.64 | NAMPT (0.59) | NPC1EPHX2MEN1KMT2ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1874775-A | 4-fluoro-4-(pyridin-2-yl)-piperidine-1-carboxamide derivatives and related compounds which modulate the function of the vanilloid-1 receptor (VR1) for the treatment of pain | MERCK SHARP & DOHME (GB) | 2006-12-06 | — | — | CN | claimed |
| CN-1874775-A | 4-fluoro-4-(pyridin-2-yl)-piperidine-1-carboxamide derivatives and related compounds which modulate the function of the vanilloid-1 receptor (VR1) for the treatment of pain | MERCK SHARP & DOHME (GB) | 2006-12-06 | — | — | CN | disclosed |