Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27425148 | 0.83 | PNMT (0.42) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL27348144 | 0.83 | PNMT (0.45) | PNMTNPC1RAB9APGRDRD2 | |
| Hydrochloric Acid SCHEMBL4447246 | 0.82 | DRD2 (0.38) | PNMTNPC1RAB9APGRDRD2 | |
| Hydrochloric Acid SCHEMBL7913247 | 0.82 | PNMT (0.36) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL28220071 | 0.81 | PNMT (0.44) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL28286932 | 0.81 | PNMT (0.44) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL6673850 | 0.81 | PNMT (0.39) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL9659755 | 0.81 | PNMT (0.37) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL28762096 | 0.81 | PNMT (0.37) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL7625230 | 0.81 | PNMT (0.37) | PNMTNPC1RAB9APGRDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100487005-C | Activating supports for metallocene catalysis | TOTAL PETROCHEMICALS RES FELUY (BE) | 2009-05-13 | — | — | CN | disclosed |
| CN-1918201-A | Activating supports for metallocene catalysis | TOTAL PETROCHEMICALS RES FELUY (BE) | 2007-02-21 | — | — | CN | disclosed |