Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9659755 | 0.84 | PNMT (0.37) | PNMTNPC1RAB9APGRDRD2 | |
| Hydrochloric Acid SCHEMBL27425148 | 0.83 | PNMT (0.42) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL27348144 | 0.83 | PNMT (0.45) | PNMTNPC1RAB9APGRDRD2 | |
| Hydrochloric Acid SCHEMBL27650656 | 0.82 | PNMT (0.36) | PNMTNPC1RAB9APGRDRD2 | |
| Hydrochloric Acid SCHEMBL4447246 | 0.82 | DRD2 (0.38) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL28286932 | 0.81 | PNMT (0.44) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL28220071 | 0.81 | PNMT (0.44) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL28762096 | 0.81 | PNMT (0.37) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL6437444 | 0.81 | PNMT (0.37) | PNMTNPC1RAB9APGRDRD2 | |
| SCHEMBL7625230 | 0.81 | PNMT (0.37) | PNMTNPC1RAB9APGRDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255425-B1 | EXTRUDED ARTICLE FORMED BY EXTRUSION OF SYNDIOTACTIC PROPYLENE HOMOPOLYMER HAVING SYNDIOTACTIC PENTAD FRACTION OF AT LEAST 0.7 | MITSUI CHEMICALS, INC. (JP) | 2001-07-03 | — | — | US | claimed |
| US-6127305-A | Catalyst and process for polymerizing alpha-olefins | ENICHEM S.P.A (IT) | 2000-10-03 | — | — | US | claimed |
| EP-0588404-B1 | Catalyst and process for polymerizing alpha-olefins | ENICHEM SPA (IT) | 1997-06-18 | — | — | EP | claimed |
| CN-1031580-C | Catalyst and process for polymerization and copolymerization of alpha-olefins | ENICHEM ANIC SPA (IT) | 1996-04-17 | — | — | CN | claimed |
| EP-0464684-B1 | Syndiotactic crystalline copolymers of propylene | SPHERILENE SRL (IT) | 1995-06-14 | — | — | EP | claimed |
| EP-0588404-A2 | Catalyst and process for polymerizing alpha-olefins | ENICHEM S.p.A. (IT) | 1994-03-23 | — | — | EP | claimed |
| EP-0464684-A2 | Syndiotactic crystalline copolymers of propylene | SPHERILENE S.r.l. (IT) | 1992-01-08 | — | — | EP | claimed |
| CN-1051363-A | The catalyzer of alpha-olefine polymerizing and copolymerization and method | ENICHEM ANIC SPA (IT) | 1991-05-15 | — | — | CN | claimed |
| JP-6087930-A | — | — | None | — | — | JP | disclosed |
| JP-5156033-A | — | — | None | — | — | JP | disclosed |
| CN-101528784-B | Process for producing syndiotactic propylene polymer | MITSU CHEMICALS INC | 2012-09-05 | — | — | CN | disclosed |
| CN-101528784-A | Process for producing syndiotactic propylene polymer | MITSUI CHEMICALS INC (JP) | 2009-09-09 | — | — | CN | disclosed |
| CN-100369967-C | Syndiotactic propylene polymer composition | MITSUI CHEMICALS INC (JP) | 2008-02-20 | — | — | CN | disclosed |
| CN-1751090-A | Syndiotactic propylene polymer composition | MITSUI CHEMICALS INC (JP) | 2006-03-22 | — | — | CN | disclosed |
| CN-1059532-A | PROPYLENE COPOLYMER | MITSUI TOATSU CHEMICALS (JP) | 1992-03-18 | — | — | CN | disclosed |
| EP-0464684-A2 | Syndiotactic crystalline copolymers of propylene | SPHERILENE S.r.l. (IT) | 1992-01-08 | — | — | EP | disclosed |
| CN-1057056-A | Novel poly-alpha olefins | MITSUI TOATSU CHEMICALS (JP) | 1991-12-18 | — | — | CN | disclosed |
| CN-1052077-A | Molded articles of syndiotactic polypropylene and manufacture method thereof | MITSUI TOATSU CHEMICALS (JP) | 1991-06-12 | — | — | CN | disclosed |
| CN-1051363-A | The catalyzer of alpha-olefine polymerizing and copolymerization and method | ENICHEM ANIC SPA (IT) | 1991-05-15 | — | — | CN | disclosed |
| EP-0422703-A1 | Catalyst and process for the polymerization and copolymerization of alpha-olefins | Enichem Anic S.r.l. (IT) | 1991-04-17 | — | — | EP | disclosed |