SCHEMBL27657643

SCHEMBL27657643

CC(=O)N(Cl)c1ccc(O)cc1[N+](=O)[O-]

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 4/20 0.44
BACE1 P56817 2/20 0.43
ALDH1A1 P00352 3/20 0.43
MAPT P10636 2/20 0.43
NPSR1 Q6W5P4 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
KCNMA1 Q12791 1/20 0.39
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
KDM4E B2RXH2 3/20 0.38
HTT P42858 1/20 0.38
MAPK1 P28482 1/20 0.37
GLA P06280 1/20 0.37
AR P10275 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
ALDH3A1 P30838 1/20 0.36
EGFR P00533 1/20 0.36
GPR35 Q9HC97 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27490657 0.83 HCAR3 (0.43) HCAR3ALDH1A1MAPTKDM4EHTT
SCHEMBL3154313 0.79 THRB (0.44) ALDH1A1MAPTNPSR1TDP1GPR35
SCHEMBL15049708 0.78 HCAR3 (0.63) HCAR3ALDH1A1MAPTNPSR1TDP1
SCHEMBL182012 0.73 HCAR3 (0.49) HCAR3BACE1ALDH1A1MAPTNPSR1
SCHEMBL2327506 0.71 BACE1 (0.45) BACE1ALDH1A1MAPTNPSR1KCNMA1
SCHEMBL9760048 0.71 HCAR3 (0.47) HCAR3BACE1ALDH1A1MAPTNPSR1
SCHEMBL688642 0.71 HCAR3 (0.51) HCAR3BACE1ALDH1A1MAPTNPSR1
Ethane SCHEMBL27988634 0.70 TSHR (0.57) BACE1ALDH1A1NPSR1ESR1ESR2
SCHEMBL6844406 0.70 HCAR3 (0.46) HCAR3BACE1ALDH1A1MAPTNPSR1
SCHEMBL29577003 0.69 TSHR (0.56) BACE1ALDH1A1NPSR1ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1966495-B Method for preparing 5-(4- fluobenzene sulphonyloxy) benzimidazole-2-amido methyl formate CHANGZHOU YABANG QIHUI FINE CHEMICALS CO LTD 2010-06-16 CN disclosed
CN-1966495-A Method for preparing 5-(4- fluobenzene sulphonyloxy) benzimidazole-2-amido methyl formate CHANGZHOU YABANG QIHUI FINE CH (CN) 2007-05-23 CN disclosed