Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.37 |
| ▸ | VEGFA | P15692 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2110554 | 0.76 | IDO1 (0.39) | IDO1VEGFAFLT1EGLN1KDM4E | |
| SCHEMBL2111844 | 0.70 | PDK1 (0.45) | VEGFAFLT1EGLN1KDM4ELMNA | |
| SCHEMBL2113204 | 0.69 | ALDH1A1 (0.43) | LMNACDK9SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14832716 | 0.69 | FTO (0.45) | IDO1KDM4EPIM1EPHX2MEN1 | |
| SCHEMBL2113926 | 0.69 | TRPM8 (0.39) | LMNACDK9HTTCYP1A2CYP3A4 | |
| SCHEMBL2112842 | 0.66 | IDO1 (0.54) | IDO1LMNASMN1; SMN2PIM1EPHX2 | |
| SCHEMBL1753343 | 0.66 | PTGDR2 (0.64) | MAPTTDP1 | |
| SCHEMBL28180078 | 0.65 | SLC6A7 (0.31) | CYP2D6CYP2C19SLC6A7 | |
| SCHEMBL1743707 | 0.64 | DYRK1A (0.44) | IDO1LMNAPIM1EPHX2MAPT | |
| SCHEMBL1093987 | 0.64 | DYRK1A (0.44) | IDO1LMNAPIM1EPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100575330-C | Novel compounds | ASTRAZENECA AB | 2009-12-30 | — | — | CN | claimed |
| CN-1791572-A | Novel compounds | ASTRAZENECA AB (SE) | 2006-06-21 | — | — | CN | claimed |
| CN-100575330-C | Novel compounds | ASTRAZENECA AB | 2009-12-30 | — | — | CN | disclosed |
| CN-1791572-A | Novel compounds | ASTRAZENECA AB (SE) | 2006-06-21 | — | — | CN | disclosed |