SCHEMBL2766482

SCHEMBL2766482

COc1cc(F)c(N2CCN(CCCC3CCCCC3)CC2)cc1F

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 1/20 0.47
DRD2 P14416 4/20 0.45
ADRA1A P35348 2/20 0.45
DRD3 P35462 2/20 0.45
HTR7 P34969 3/20 0.44
HTR1A P08908 2/20 0.44
DRD4 P21917 2/20 0.42
SIGMAR1 Q99720 2/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
HTR2A P28223 1/20 0.41
HTR2C P28335 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2767200 0.99 FFAR4 (0.47) FFAR4DRD2ADRA1ADRD3HTR7
SCHEMBL2766230 0.97 DRD2 (0.46) FFAR4DRD2ADRA1ADRD3HTR7
SCHEMBL2766456 0.93 FFAR4 (0.48) FFAR4DRD2ADRA1ADRD3HTR7
SCHEMBL2766664 0.88 FFAR4 (0.50) FFAR4
SCHEMBL2769261 0.82 DRD2 (0.38) DRD2ADRA1ADRD3HTR7HTR1A
SCHEMBL2767573 0.81 DRD2 (0.39) DRD2ADRA1ADRD3HTR7HTR1A
SCHEMBL2765904 0.79 HTR1A (0.60) DRD2ADRA1ADRD3HTR1ADRD4
SCHEMBL2766431 0.79 ADRA1B (0.38) DRD2ADRA1ADRD3HTR7HTR1A
SCHEMBL2768765 0.75 CHRM4 (0.47) DRD2DRD3HTR7HTR1ADRD4
SCHEMBL2767124 0.74 DRD2 (0.42) DRD2ADRA1ADRD3HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1627871-B1 CYCLIC AMINOPHENYL SULFAMATE DERIVATIVE ASKA PHARM CO LTD (JP) 2010-04-14 EP disclosed
US-7449466-B2 Cyclic aminophenyl sulfamate derivative ASKA PHARMACEUTICAL CO., LTD. (JP) 2008-11-11 US disclosed
US-20060189625-A1 Cyclic aminophenyl sulfamate derivative ASKA PHARMACEUTICAL CO., LTD. (JP) 2006-08-24 US disclosed
EP-1627871-A1 CYCLIC AMINOPHENYL SULFAMATE DERIVATIVE Teikoku Hormone Mfg. Co., Ltd. (JP) 2006-02-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060189625-A1 Cyclic aminophenyl sulfamate derivative SHBG, STS, ARSA FFAR4 2828/4885DRD2 3225/4885ADRA1A 2425/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.