SCHEMBL2767459

SCHEMBL2767459

CNc1cc(Cl)nc(Cl)c1[N+](=O)[O-]

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.51
KMT2A Q03164 4/20 0.51
POLB P06746 3/20 0.51
ALDH1A1 P00352 3/20 0.51
MEN1 O00255 3/20 0.51
LMNA P02545 2/20 0.51
RAB9A P51151 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
HTT P42858 2/20 0.51
NPC1 O15118 2/20 0.51
OPRD1 P41143 2/20 0.51
OPRK1 P41145 2/20 0.51
TLR9 Q9NR96 2/20 0.51
MAPK1 P28482 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
GPR55 Q9Y2T6 1/20 0.51
GALR2 O43603 1/20 0.39
TSHR P16473 2/20 0.37
TDP1 Q9NUW8 1/20 0.36
HCAR3 P49019 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30542027 1.00 MAPT (0.51) MAPTKMT2APOLBALDH1A1MEN1
SCHEMBL25368037 0.86 MAPT (0.51) MAPTKMT2APOLBALDH1A1MEN1
SCHEMBL413683 0.85 MAPT (0.50) MAPTKMT2APOLBALDH1A1MEN1
SCHEMBL13997802 0.82 PGK1 (0.44) MAPTKMT2APOLBALDH1A1MEN1
SCHEMBL19690963 0.82 GLP1R (0.41) MAPTKMT2APOLBALDH1A1MEN1
SCHEMBL12544826 0.81 MAPT (0.40) MAPTKMT2APOLBALDH1A1MEN1
SCHEMBL27028466 0.80 MAPT (0.46) MAPTKMT2APOLBALDH1A1MEN1
SCHEMBL25363603 0.80 ALDH1A1 (0.46) MAPTKMT2APOLBALDH1A1MEN1
SCHEMBL1630321 0.80 ALDH1A1 (0.46) MAPTKMT2APOLBALDH1A1MEN1
SCHEMBL27028461 0.80 MEN1 (0.46) MAPTKMT2APOLBALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720057-A2 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF Oncopia Therapeutics, Inc. D/B/A SK Life Science Labs (US) 2026-04-08 EP disclosed
WO-2025049976-A1 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) 2025-03-06 WO disclosed
WO-2024249888-A2 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) 2024-12-05 WO disclosed
US-20240383903-A1 Modulators of STING (Stimulator of Interferon Genes) PFIZER INC. (US) 2024-11-21 US disclosed
US-20240317705-A1 POTASSIUM CHANNEL MODULATORS NOVARTIS AG (CH) 2024-09-26 US disclosed
US-11964978-B2 Modulators of STING (stimulator of interferon genes) PFIZER INC. (US) 2024-04-23 US disclosed
EP-4308563-A1 MODULATORS OF STING (STIMULATOR OF INTERFERON GENES) Pfizer Inc. (US) 2024-01-24 EP disclosed
CN-117321055-A Modulators of STING (interferon gene stimulators) 辉瑞公司 2023-12-29 CN disclosed
CN-117186092-A Ring-fused compound, preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2023-12-08 CN disclosed
CN-117088871-A Ring-fused compound, preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2023-11-21 CN disclosed
EP-1888584-B1 1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2010-04-21 EP disclosed
US-20100035934-A1 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S 2010-02-11 US disclosed
EP-2114916-A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NeuroSearch A/S (DK) 2009-11-11 EP disclosed
US-7557211-B2 8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same BRISTOL-MYERS SQUIBB COMPANY (US) 2009-07-07 US disclosed
US-7557211-B2 8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same BRISTOL-MYERS SQUIBB COMPANY (US) 2009-07-07 US disclosed
WO-2008092942-A2 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S (DK) 2008-08-07 WO disclosed
EP-1888584-A1 1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY Brystol-Myers Squibb Company (US) 2008-02-20 EP disclosed
US-20060270654-A1 1,6-Dihydro-1,3,5,6-Tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same BRISTOL-MYERS SQUIBB COMPANY 2006-11-30 US disclosed
WO-2006122137-A1 1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2006-11-16 WO disclosed
US-20060128741-A1 8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same BRISTOL-MYERS SQUIBB COMPANY 2006-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240317705-A1 POTASSIUM CHANNEL MODULATORS KCNJ11, KCNJ2, KCNJ1 MAPT 2009/4885KMT2A 1471/4885POLB 4802/4885
US-20100035934-A1 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS KCNJ2, KCNA3, KCNQ1 MAPT 1538/4885KMT2A 1455/4885POLB 4745/4885
US-20060270654-A1 1,6-Dihydro-1,3,5,6-Tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same IL1R1, IDO1, TLR1 MAPT 1426/4885KMT2A 3054/4885POLB 4295/4885
US-11964978-B2 Modulators of STING (stimulator of interferon genes) STING1, IRF3, CGAS MAPT 4690/4885KMT2A 4571/4885POLB 185/4885
US-20240383903-A1 Modulators of STING (Stimulator of Interferon Genes) STING1, IRF3, CGAS MAPT 4690/4885KMT2A 4571/4885POLB 185/4885
US-20060128741-A1 8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same IL4, IL5, CYP4B1 MAPT 2177/4885KMT2A 1969/4885POLB 3193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.