Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920808 | 0.87 | KDM4E (0.41) | S1PR1S1PR3LMNAALDH1A1KDM4E | |
| SCHEMBL27693464 | 0.87 | LMNA (0.44) | LMNAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL27675276 | 0.87 | LMNA (0.42) | LMNAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL27693550 | 0.86 | NTRK1 (0.43) | S1PR1S1PR3LMNAALDH1A1 | |
| SCHEMBL27693577 | 0.86 | LMNA (0.46) | LMNAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL27693531 | 0.85 | CHRM1 (0.41) | LMNAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL27675140 | 0.84 | ALDH1A1 (0.40) | LMNAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL27693536 | 0.84 | KDM4E (0.39) | LMNAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL27675121 | 0.84 | CHRM1 (0.47) | S1PR1S1PR3CAPN1LMNAKDM4E | |
| SCHEMBL27693494 | 0.84 | LMNA (0.40) | LMNAALDH1A1KDM4EPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |