Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675278 | 0.89 | CFD (0.39) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL27920808 | 0.89 | KDM4E (0.41) | ALDH1A1SMN1; SMN2KDM4EPOLBHPGD | |
| SCHEMBL27693464 | 0.89 | LMNA (0.44) | ALDH1A1SMN1; SMN2KDM4EPOLBHPGD | |
| SCHEMBL27675177 | 0.87 | CREBBP (0.44) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL27675276 | 0.86 | LMNA (0.42) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL27693536 | 0.86 | KDM4E (0.39) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL27693577 | 0.85 | LMNA (0.46) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL27675381 | 0.85 | CFTR (0.48) | ALDH1A1SMN1; SMN2KDM4ELMNACFTR | |
| SCHEMBL27693531 | 0.84 | CHRM1 (0.41) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL27675213 | 0.84 | HTT (0.46) | ALDH1A1KDM4EPOLBHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |