Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27675276 | 0.87 | LMNA (0.42) | POLBHPGDALDH1A1LMNAEP300 | |
| SCHEMBL27991300 | 0.86 | KDM4E (0.43) | POLBHPGDALDH1A1HTTL3MBTL1 | |
| SCHEMBL28766939 | 0.86 | S1PR1 (0.43) | POLBHPGDALDH1A1LMNAKMT2A | |
| SCHEMBL27693564 | 0.84 | EP300 (0.43) | POLBHPGDALDH1A1HTTTDP1 | |
| SCHEMBL27693515 | 0.84 | CREBBP (0.46) | POLBHPGDALDH1A1HTTLMNA | |
| SCHEMBL27675229 | 0.84 | KDM4E (0.45) | POLBHPGDALDH1A1L3MBTL1LMNA | |
| SCHEMBL27675331 | 0.83 | CFD (0.41) | POLBHPGDALDH1A1LMNAKDM4E | |
| SCHEMBL27693557 | 0.83 | LMNA (0.40) | POLBHPGDALDH1A1TDP1L3MBTL1 | |
| SCHEMBL27920808 | 0.82 | KDM4E (0.41) | POLBHPGDALDH1A1L3MBTL1LMNA | |
| SCHEMBL27693464 | 0.82 | LMNA (0.44) | POLBHPGDALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006076-B | Modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2010-09-29 | — | — | CN | disclosed |
| CN-101006076-A | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2007-07-25 | — | — | CN | disclosed |