Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2705078 | 0.81 | KDM4E (0.46) | KDM4EKMT2APOLBTSHRHSD17B10 | |
| SCHEMBL28215241 | 0.78 | KDM4E (0.46) | KDM4EKMT2APOLBTSHRHSD17B10 | |
| SCHEMBL7118447 | 0.74 | SRD5A2 (0.59) | KDM4ETSHRHSD17B10CDC25ACDC25B | |
| SCHEMBL15100954 | 0.74 | CDC25A (0.48) | KDM4EKMT2APOLBTSHRHSD17B10 | |
| SCHEMBL11685106 | 0.73 | AKR1C3 (0.51) | KDM4EKMT2ATSHRALDH1A1MEN1 | |
| SCHEMBL8962320 | 0.72 | CDC25B (0.77) | KDM4EKMT2APOLBTSHRHSD17B10 | |
| SCHEMBL257668 | 0.72 | CDC25A (0.46) | KDM4EKMT2APOLBTSHRHSD17B10 | |
| SCHEMBL250099 | 0.72 | CES2 (0.71) | KMT2ACES2CES1ALDH1A1MEN1 | |
| SCHEMBL30293901 | 0.72 | CES2 (0.71) | KMT2ACES2CES1ALDH1A1MEN1 | |
| SCHEMBL9178259 | 0.70 | ALDH1A1 (0.61) | KMT2AHSD17B10CDC25ACDC25BCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101014603-A | Compounds and methods for inhibiting mitosis by inhibiting aurora kinase | MILLENNIUM PHARM INC (US) | 2007-08-08 | — | — | CN | disclosed |