Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.56 |
| ▸ | HTR7 | P34969 | 8/20 | 0.53 |
| ▸ | HTR1A | P08908 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR5A | P47898 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | HTR3A | P46098 | 4/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.42 |
| ▸ | HTR3B | O95264 | 2/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27687362 | 0.81 | HTR6 (0.57) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL27687352 | 0.81 | HTR1A (0.54) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL4909469 | 0.79 | HTR7 (0.58) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL7055201 | 0.79 | HTR7 (0.57) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL3218230 | 0.77 | HTR3A (0.47) | HTR6HTR7HTR1AHTR2AHTR5A | |
| Trifluoroacetic Acid SCHEMBL28779025 | 0.72 | BACE1 (0.43) | HTR6HTR7HTR1AHTR2AHTR5A | |
| Pyridine SCHEMBL28147257 | 0.72 | HTR1A (0.46) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL10566917 | 0.72 | HTR6 (1.00) | HTR6HTR7HTR1AHTR2AHTR5A | |
| SCHEMBL29915638 | 0.71 | ADRB1 (0.41) | HTR6HTR7HTR1AADRB2HTR2B | |
| SCHEMBL5566823 | 0.70 | HTR7 (0.63) | HTR6HTR7HTR1AHTR2AHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101084205-A | N-biaryl and n-arylheteroaryl piperazine derivatives as modulators of the 5ht2c receptor useful for the treatment of disorders related thereto | ARENA PHARM INC (US) | 2007-12-05 | — | — | CN | claimed |
| CN-101084205-A | N-biaryl and n-arylheteroaryl piperazine derivatives as modulators of the 5ht2c receptor useful for the treatment of disorders related thereto | ARENA PHARM INC (US) | 2007-12-05 | — | — | CN | disclosed |