Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28767581 | 0.88 | ALOX5 (0.43) | ALOX5THRBLMNAPOLBTP53 | |
| SCHEMBL27716085 | 0.81 | ADK (0.31) | ADKPIK3CAMTOR | |
| SCHEMBL27696229 | 0.80 | MTOR (0.33) | ADKALDH1A1PIK3CAMTOR | |
| SCHEMBL27716128 | 0.79 | BCHE (0.34) | ADKALDH1A1PIK3CAMTOR | |
| SCHEMBL27696224 | 0.78 | PTGES (0.44) | ALOX5POLBNPC1RAB9A | |
| SCHEMBL27696377 | 0.77 | PTGES (0.39) | PDK1 | |
| SCHEMBL27696205 | 0.74 | KDM4E (0.34) | LMNAPOLBPKMALDH1A1PIK3CA | |
| SCHEMBL3582789 | 0.74 | AURKB (0.42) | TP53ALDH1A1 | |
| SCHEMBL27716183 | 0.74 | HSD17B10 (0.35) | LMNAALDH1A1PIK3CAMTOR | |
| SCHEMBL4721937 | 0.73 | ADK (0.37) | ALOX5ADKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101137652-A | Pyrimidine compounds having tie2 (tek) inhibitory activity | ASTRAZENECA AB (SE) | 2008-03-05 | — | — | CN | disclosed |