Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 2/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27696203 | 0.77 | FFAR1 (0.36) | GAA | |
| SCHEMBL3575790 | 0.76 | KDR (0.44) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL27696205 | 0.75 | KDM4E (0.34) | GAALMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL27716085 | 0.74 | ADK (0.31) | PTGDR2PIK3CAMTOR | |
| SCHEMBL27696271 | 0.74 | ALOX5 (0.41) | LMNAALDH1A1PIK3CAMTOR | |
| SCHEMBL27696229 | 0.74 | MTOR (0.33) | HSD17B10ALDH1A1CYP1A2PTGDR2PIK3CA | |
| SCHEMBL27716128 | 0.72 | BCHE (0.34) | ALDH1A1HPGDPTGDR2PIK3CAMTOR | |
| SCHEMBL27696224 | 0.71 | PTGES (0.44) | HPGDPTGDR2 | |
| SCHEMBL27696377 | 0.71 | PTGES (0.39) | GAA | |
| SCHEMBL4721937 | 0.70 | ADK (0.37) | PTGDR2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101137652-A | Pyrimidine compounds having tie2 (tek) inhibitory activity | ASTRAZENECA AB (SE) | 2008-03-05 | — | — | CN | disclosed |